丙戊酸钠对癫痫儿童脂代谢的影响及其作用机制研究

杜娆, 李岩, 虞勋, 王诚*

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (11) : 982-985.

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中国药学杂志 ›› 2014, Vol. 49 ›› Issue (11) : 982-985. DOI: 10.11669/cpj.2014.11.018
论 著

丙戊酸钠对癫痫儿童脂代谢的影响及其作用机制研究

  • 杜娆1, 李岩1, 虞勋2, 王诚1*
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Effect of Sodium Valproate on Lipid Metabolism in Children with Epilepsy and its Mechanisms

  • DU Rao1, LI Yan1, YU Xun2, WANG Cheng1*
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摘要

目的 研究丙戊酸钠对癫痫儿童脂代谢的影响及其可能的作用机制。方法 测定服用丙戊酸钠不同时间后癫痫患儿的体重指数和血清中脂代谢相关指标, 并用Realtime PCR方法检测服药患儿外周血中核内过氧化体增殖物激活受体γ mRNA表达。结果 服用丙戊酸钠后癫痫患儿的体重指数, 血清中总胆固醇、甘油三酯、低密度脂蛋白-胆固醇、载脂蛋白B均明显上升(P<0.05或P<0.01), 并呈一定的时间依赖趋势。服用丙戊酸钠1年以上患儿肝功能与服药前出现了统计学差异(P<0.01)。服药患儿外周血中核内过氧化体增殖物激活受体mRNA表达显著降低(P<0.05)。结论 服用丙戊酸钠会对癫痫儿童脂代谢产生影响, 其作用机制可能与丙戊酸钠下调服药患儿体内核内过氧化体增殖物激活受体mRNA表达有关。

Abstract

OBJECTIVE To examine the effect of sodium valproate on lipid metabolism in children with epilepsy and investigate the potential mechanisms. METHODS The body mass index(BMI), the levels of serum total cholesterol(TC), triglyceride(TG), low density lipoprotein-cholesterol(LDL-C), high density lipoprotein-cholesterol (HDL-C), LDL-C/HDL-C, apolipoprotein AI(ApoAI) and apolipoprotein B(ApoB) of epilepsy children treated with sodium valproate after different time were measured.The gene expression of PPARγ in children′s peripheral blood was examined by Realtime-PCR. RESULTS The epilepsy children′s BMI, the levels of serum TC, TG, LDL-C and AproB were increased(P<0.05 or P<0.01) after treatment with sodium valproate different time.The liver function has significant difference between untreated epilepsy children and epilepsy children treated with sodium valproate more than one year. Sodium valproate could significantly increase the mRNA expression of PPARγ(P<0.05) in epilepsy children. CONCLUSION Sodium valproate has effect on lipid metabolism in epilepsy children and the mechanisms might be associated with its regulation of the PPARγ mRNA expression.

关键词

丙戊酸钠 / 癫痫 / 脂代谢 / 儿童PPARγ

Key words

sodium valproate / epilepsy / lipid metabolism / children PPARγ

引用本文

导出引用
杜娆, 李岩, 虞勋, 王诚*. 丙戊酸钠对癫痫儿童脂代谢的影响及其作用机制研究[J]. 中国药学杂志, 2014, 49(11): 982-985 https://doi.org/10.11669/cpj.2014.11.018
DU Rao, LI Yan, YU Xun, WANG Cheng*. Effect of Sodium Valproate on Lipid Metabolism in Children with Epilepsy and its Mechanisms[J]. Chinese Pharmaceutical Journal, 2014, 49(11): 982-985 https://doi.org/10.11669/cpj.2014.11.018
中图分类号: R965   

参考文献

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基金

苏州市科技局基金项目(SYSD2011141)
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